Al Soor Specialist Clinic

Depression: Symptoms and Signs


  • Depression is a complex mental health condition that affects millions worldwide.
  • Recognizing its symptoms and signs is crucial for timely diagnosis and effective treatment.
  • Eary treatment gives the best results.
  • Standard diagnostic criteria are available – DSM5 and ICD-10 criteria are commonly used by clinicians.

Symptoms of Depression:

(Symptoms refer to complaints made by the patient)

  1. Persistent Sadness:
    • Feeling down or hopeless for most of the day, nearly every day.
    • An enduring sense of emptiness or despair.
    • A diurnal variation in mood (worse in the morning, or sometimes, worse in the evening) is sometimes seen.
  2. Loss of Interest:
    • Diminished interest or pleasure in activities once enjoyed.
    • Withdrawal from social interactions and hobbies.
  3. Changes in Appetite or Weight:
    • Significant weight loss or gain without intentional dieting.
    • Altered appetite, leading to overeating or undereating.
  4. Sleep Disturbances:
    • Insomnia, characterized by difficulty falling asleep or staying asleep.
    • Hypersomnia, excessive sleeping or feeling unrested after ample sleep.
  5. Fatigue and Low Energy:
    • Persistent feelings of tiredness and low energy levels.
    • Even simple tasks may feel exhausting.
  6. Agitation or Restlessness:
    • Feeling restless, pacing, or unable to sit still.
    • Irritability or impatience over minor matters.
  7. Feelings of Worthlessness or Guilt:
    • Excessive guilt over past events or perceived shortcomings.
    • A pervasive sense of inadequacy or self-blame.
  8. Difficulty Concentrating:
    • Trouble focusing, making decisions, or remembering details.
    • Cognitive fog or mental slowness.
  9. Physical Symptoms:
    • Unexplained aches, pains, or digestive issues.
    • Headaches, stomach-aches, or backaches with no clear cause.
  10. Suicidal Thoughts or Behaviours:
    • Recurrent thoughts of death, suicide, or self-harm.
    • Engaging in risky behaviours or making plans for suicide.

Signs of Depression:

(Signs refer to observations that can be made by others)

  1. Changes in Behaviour:
    • Social withdrawal or isolation.
    • Decreased productivity at work or school.
  2. Neglecting Responsibilities:
    • Ignoring household chores, bills, or personal hygiene.
    • Difficulty fulfilling obligations due to lack of motivation.
  3. Substance Abuse:
    • Increased reliance on alcohol, drugs, or medications.
    • Substance misuse as a coping mechanism.
  4. Expressing Hopelessness:
    • Vocalizing feelings of despair or worthlessness.
    • Statements suggesting a bleak outlook on the future.
  5. Physical Complaints:
    • Visiting doctors frequently with vague physical complaints.
    • Seeking medical help for symptoms with no apparent cause.
  6. Changes in Appearance:
    • Neglecting personal grooming or hygiene.
    • Weight changes or decline in physical health.

Other Clinical Features of Depression:

  1. Duration and Severity:
    • Symptoms must persist for at least two weeks to be considered clinically significant for a diagnosis of Depression.
    • Severity varies from mild to severe, impacting daily functioning.
  2. Psychomotor Retardation or Agitation:
    • Some individuals may exhibit slowed movements or speech.
    • Others may display restlessness or agitation.
  3. Psychological Impact:
    • Depression affects all aspects – thoughts, emotions, and behaviour.
    • Distorted thinking patterns such as negative self-talk or catastrophizing are typical of depression.
  4. Interpersonal Difficulties:
    • Strained relationships due to withdrawal or irritability are common in Depression.
    • Difficulty expressing emotions or connecting with others is frequently observed.
  5. Comorbidity:
    • Depression often coexists with other mental health disorders like anxiety or substance abuse.
    • This increases the complexity of diagnosis and treatment.
  6. Impact on Daily Life:
    • Impairs functioning in various domains: work, school, relationships, and self-care.
    • Diminished quality of life and productivity.


  • Depression is a multifaceted disorder characterized by a myriad of symptoms or signs.
  • Recognizing these manifestations is crucial for timely diagnosis and effective management.
  • Early intervention, including therapy, medication, and support systems, can alleviate the burden of depression and improve overall well-being.